1.
The
nucleic acid of a virus has a 2 On The number of purines is equal to the number
of pyrimidines
Which
of these nucleic acids is the virus most likely to have as its genome?
A
Double-stranded DNA
B.
Single-stranded DNA
C
Double-stranded RNA
D.
Single-stranded RNA
2.
ISSATGGCATGCAATAGCTC-3'
is sense strand of DNA, what is it's RNA transcript
A.
SATGGCATOCAATAGCTC-3'
B3-AUGGCAUCCAALAGCUC-3
C.5
TACCGTACGTTATCGAG-3)
D.
5.AUGGCAUGCAAUAGCUC-3
3.
ISATG
GCATGCAATAGCGTC-3' is sense strand of DNA, one of the following is correct
codon translated:
A.
AUG, GCA, UGC, AAU,AGC, GUC
B.
UAC, CGU, ACG, UUA, UCG, CAG
BC
TAC. CGU, ACG, UUA, UCG, CAG
D.
ATG, GCA.. TGC, AAT, AGC, GTC
4.
One
of the following factor is not favor annealing of DNA strands
A.
Decrease in temperature
B.
Decrease in PH
C.
Increase in salt concentration
D.
Acidic environments
5.
The
simplest and smallest non-coding RNA
A.
rRNA B. tRNA C. mRNA D. snRNA
6.
One
of the following codon is not represent the end of the gene translation
A.
UAA
B.UAG
C.
UGA
D.
UGG
7.
One
of the following mutation resulted prematurely terminated protein synthesis due
to Insertion and deletions of single base
A.
Frame shift mutation
B.
Missense mutation
C.
Nonsense mutation
8.
Xeroderma
pigmentosum is a group of genetic disease usually occasioned due to mutations
in:
A.
Enzymes/proteins involved in nucleotide excision repair.
B.
Enzymes/proteins involved in base excision repair
C.
Enzymes/proteins involved in mismatch repair
9.
The
specialized structures located at the ends of the eukaryotic chromosomes are
called:
A.
Terminators.
B.
Terminal untranslated sequence E. Translation stop signal.
C.
Telomeres. D. TATA box.
10.
An
E. Coli lacking the DNA polymerase I will be deficient in:
A.
DNA repair.
C.
DNA methylation.
D.
Pre-mRNA splicing.
B.
Transcription. -
E.
Chromatin condensation.
11.
If
the following is the part of an oncogene frequently activated by mutation in
tumors as compared
to
the normal sequence. What type of mutation is it?
Normal:
ATGACGGAATATAAGCTGGTGGTGGTGGGCGCCGGCGGT
Mutant:
ATGACGGAATATAAGCTGGTGGTGGTGGGCGCCGTCGGT
A.
An insertion that causes frame-shifting of the protein
B. A
deletion that causes frame-shifting of the protein.
C. A
missense mutation that changes one amino acid within the protein
D. A
silent mutation with normal amino acid sequence of the protein.
E. A
non-sense mutation with truncated protein.
12.
The
mutation that causes Xeroderma Pigmentosum affects:
A.
The primase gene.
B.
Nucleotide excision repair.
C.
Mismatch repair components.
D.
Synthesis DNA across the damaged region.
E.
Proofreading capacity.
13.
The
nucleic acid of a virus has a 2'-OH. The number of purines is equal to the
number of pyrimidines. Which of these nucleic acids is the virus most likely to
have as its genome?
A.
Double-stranded DNA
B.
Single-stranded DNA
C.
Double-stranded RNA
D.
Single-stranded RNA
14.
If
5'-ATGGCATGCAATAGOTC-3' is sense strand of DNA, what is it's RNA transcript?
A.
5'-ATGGCATGCAATAGCTC-3"
B.
S'-TACCGTACGTTATCGAG-3'
C.
5'-AUGGCAUCCAAUAGCUC-3'
D.
5°-AUGGCAUGCAAUAGCUC-3°
15.
One
of the following statement is correct about the Mechanism of DNA Replication?
A.
DNA synthesis on the leading strand is continuous.
B.
The lagging strand grows the same general direction as the leading strand.
C.
DNA is made in the 5'-to-3' direction of the template DNA strand.
D.
All are correct
E.
None of the above
16.
Which
one of the following causes the double-stranded DNA to melt (separate), form localized
regions of single standed DNA." A. Single-stranded DNA binding proteins
B.
DNA helicases
C.
Dna proteins
D. A
and C are answers
E.
None of the above
17.
The
process involved in the RNA formation on the DNA template is
A.
Transcription
B.
Translation
C.
Replication
D.
Transformation
E.
None of the above
18.
Transcription
is the transfer of genetic information from
A.
DNA to RNA
B.
tRNA to mRNA
C.
DNA to mRNA
D.
mRNA to tRNA
19.
RNA
required for the protein synthesis
A.
mRNA - B. ERNA C. IRNA D.
All of these
20.
A
promoter site on DNA
A.
Initiates transcription
B.
Regulates termination
C.
Codes for RNA
D.
Transcribes repressor
21.
What
is the main function of tRNA in relation to protein synthesis?
A.
Inhibits protein synthesis
B.
Proof reading
C.
Identifies amino acids and transport them to ribosomes
D.
All of the above
E.
None of the above
22.
Which
site of tRNA molecule hydrogen bonds to a mRNA molecule?
A.
Codon
B.
Anticodon
C.
5'ends of the tRNA molecule
D.
3'ends of the tRNA molecule
23.
A
12-year-old girl is brought to the dermatologist and the parents report that
she is unusually sensitive to sunlight. Two basal cell carcinomas are
identified on her face. Which of the following processes is most likely to be
defective in this patient?
A.
Repair of double-strand breaks.
B.
Removal of mismatched bases from the 3'-end of Okazaki fragments.
C.
Removal of pyrimidine dimers from DNA.
D.
Removal of uracil from DNA.
24.
In
the synthesis of telomeres:
A.
telomerase provides both the RNA and the polymerase needed for synthesis.
B.
the RNA of telomerase serves as a primer.
C.
the polymerase of telomerase is a DNA-directed DNA polymerase.
D.
the shorter, 3' 5' strand gets extended.
E.
the direction of synthesis is 3' - 5'.
25.
The
codon is found on, and the anticodon is found on
A.
TRNA, mRNA
B.
rRNA, RNA
C.
ribosomes, tRNA
D.
mRNA, RNA
E.
mRNA, rRNA
26.
Which
of the following dimer formation is most common?
A.
thymidine dimer
B.
cytidine dimer
C.
both a and b
27.
Dimer
repair mechanism include:
A.
excision repair
B.
photoreactivation
C.
recombinational repair
D.
all of these
28.
DNA
glycosylase is an enzyme involved in base excision repair. The function is:
A.
addition of correct base
B.
addition of correct nucleotide
C.
removal of incorrect base
D.
removal of phosphodiester bond
29.
In
the synthesis of telomeres:
A.
telomerase provides both the RNA and the polymerase needed for synthesis.
B.
the RNA of telomerase serves as a primer.
C.
the polymerase of telomerase is a DNA-directed DNA polymerase.
D.
the shorter, 3' 5' strand gets extended.
E.
the direction of synthesis is 3' +5'.
30.
The
codon is found on, and the anticodon is found on
A.
TRNA, mRNA
B.
rRNA, RNA
C.
ribosomes, tRNA
D.
mRNA, RNA
E
mRNA, rRNA
31.
Which
of the following dimer formation is most common?
A.
thymidine dimer
B.
cytidine dimer
C.
both a and b
D.
none of these
32.
Dimer
repair mechanism include:
A.
excision repair
B.
photoreactivation
C.
recombinational repair
D.
all of these
33.
DNA
glycosylase is an enzyme involved in base excision repair. The function is:
A.
addition of correct base
B.
addition of correct nucleotide
C.
removal of incorrect base
D.
removal of phosphodiester bond